HORDB

ID: hor003050
Uniprot ID: P0C0P6
Protein name: Neuropeptide S
Gene name: Nps
Organism: Homo sapiens (Human)
Family: Neuropeptide S family
Source: Human
Expression: NA
Disease: NA
Comments: NA
Taxonomy: Homo (genus), Homininae (subfamily), Hominidae (family), Hominoidea (superfamily), Catarrhini (parvorder), Simiiformes (infraorder), Haplorrhini (suborder), Primates (order), Euarchontoglires (superorder), Boreoeutheria, Eutheria, Theria, Mammalia (class), Amniota, Tetrapoda, Dipnotetrapodomorpha, Sarcopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: NA
GO BP: GO:0007218 neuropeptide signaling pathway; GO:0008542 visual learning; GO:0010841 positive regulation of circadian sleep/wake cycle, wakefulness; GO:0032230 positive regulation of synaptic transmission, GABAergic; GO:0035249 synaptic transmission, glutamatergic; GO:0045760 positive regulation of action potential; GO:0051968 positive regulation of synaptic transmission, glutamatergic
GO CC: GO:0005576 extracellular region; GO:0045202 synapse

Sequence: SFRNGVGTGMKKTSFQRAKS
Length: 20(70-89)
Propeptide: MISSVKLNLILVLSLSTMHVFWCYPVPSSKVSGKSDYFLILLNSCPTRLDRSKELAFLKPILEKMFVKRSFRNGVGTGMKKTSFQRAKS
Signal peptide: MISSVKLNLILVLSLSTMHVFWC
Modification: NA
Glycosylation: NA
Mutagenesis: NA

Function: Modulates arousal and anxiety. May play an important anorexigenic role (By similarity). Binds to its receptor NPSR1 with nanomolar affinity to increase intracellular calcium concentrations
Mechanism: NA
Cross BBB: NA
Target: NPSR1
Target Unid: Q6W5P4
IC50: NA
EC50: NA
ED50: NA
kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

AF-O48776-F1.pdb

hor003050_AF2.pdb

hor003050_ESM.pdb

Mass:	252656	Formula:	C93H155N31O28S
Absent amino acids:	CDEHILPWY	Common amino acids:	GKS
pI:	12.55	Basic residues:	5
Polar residues:	9	Hydrophobic residues:	4
Hydrophobicity:	-96	Boman Index:	-5703
Half-Life:	1.9 hour	Half-Life Yeast:	>20 hour
Half-Life E.Coli:	>10 hour	Aliphatic Index	19.5
Instability Index:	-458	Extinction Coefficient cystines:	0
Absorbance 280nm:	0